Accession Number:

AD0712666

Title:

EFFECTS OF HISTAMINE ON THE CEREBRAL VASCULATURE IN RHESUS MONKEYS.

Descriptive Note:

Final rept. Jan-Mar 70,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

Report Date:

1970-07-01

Pagination or Media Count:

14.0

Abstract:

Cerebral angiography was performed on 20 rhesus monkeys, and the systemic blood pressure of these and 4 additional animals was monitored to determine the effects of injected doses of 150 and 300 microgramskg. of histamine. No significant difference was observed in the vessel diameters of the 150 microgramskg. group however, the 300 microgramskg. group exhibited maximum constriction of the anterior cerebral artery 4 minutes after injection of histamine. Blood pressure fell rapidly until 1 to 4 minutes after the injections, at which time recovery progressed to 90 to 100 of preinjection levels in 30 minutes. Slight dilatation 103-104 of the anterior cerebral artery was in evidence 15 minutes after histamine administration. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE