Accession Number:

AD0712179

Title:

THE POSSIBLE MEDIATION BY CYCLIC AMP OF THE STIMULATION OF THYMOCYTE PROLIFERATION BY VASOPRESSIN AND THE INHIBITION OF THIS MITOGENIC ACTION BY THYROCALCITONIN,

Descriptive Note:

Corporate Author:

NATIONAL RESEARCH COUNCIL OF CANADA OTTAWA (ONTARIO) DIV OF BIOLOGY

Report Date:

1970-04-15

Pagination or Media Count:

12.0

Abstract:

Lysine vasopressin antidiuretic hormone, like cyclic adenosine 3,5-monophosphate cyclic AMP, rapidly in less than 1 hour stimulates the initiation of deoxyribonucleic acid synthesis and thereby increases the flow of cells into mitosis in rat thymic lymphocyte populations in vitro. This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the intracellular phosphodiesterase which catalyzes the degradation of cyclic AMP. On the other hand, vasopressins mitogenic action also like that of cyclic AMP is blocked by imidazole, an activator of cyclic nucleotide phosphodiesterase activity. The hormone, thyrocalcitonin calcitonin which is known to block the cyclic AMP-mediated mitogenic effect of parathyroid hormone by interfering with cyclic AMP action, also blocks the mitogenic action of vasopressin. The inhibitory effects of imidazole and thyrocalcitonin on vasopressins mitogenic action are both overcome by the phosphodiesterase inhibitor, caffeine. It is concluded from these observations that the mitogenic action of vasopressin is mediated by cyclic AMP. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE