COMPARATIVE STUDY OF ANTIMALARIAL AND OTHER DRUGS ON G6PD DEFICIENT RED CELLS.
Final technical rept. May 69-May 70,
GENOA UNIV (ITALY) ISTITUTO DI CLINICA MEDICA
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The effects of various dosages of DFD Di-N-formyl-diaminophenyl sulfone on normal and G6PD Glucose-6 phosphate dehydrogenase deficient red cells belonging to 25 Sardinian and Negro donors and transfused into 30 normal recipients were studied. 1 Single dosages of DFD, from 400 to 1200 mg, have definite hemolytic effects on G6PD deficient, not on normal red cells. 2 The destruction of the G6PD deficient red cells by DFD is dose related. 3 The borderline dosages are different if one deals with red cells belonging to G6PD deficient Sardinians or Negroes. 4 The G6PD deficient red cells belonging to Negroes are destroyed by single dosages of DFD around 800 mg. 6 Methemoglobinemia in normal recipients, receiving DFD increased only after the administration of single dosages of 1200 and 800 mg of the drug. Author