ANTIGENIC AND BIOLOGICAL CLASSIFICATION OF DENGUE VIRUSES.
Final rept. 1 Nov 66-31 Oct 69,
YALE UNIV NEW HAVEN CONN SCHOOL OF MEDICINE
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Dengue viruses are the cause of two distinct diseases, dengue fever DF, a mild and self limited illness and dengue hemorrhagic fever DHF, a severe disease with an appreciable mortality rate. This investigation addressed itself to the hypothesis that two subpopulations of dengue viruses exist, virulent and avirulent, and that the virulence of a dengue infection is correlated with identifiable antigenic markers on the virus. In addition, an attempt was made to evaluate in sub-human primates the hypothesis that a second dengue infection is modified by host factors to result in more severe disease response. Author