RESISTANCE TO BACTERIAL INFECTION INDUCED BY STATOLON AND PYRAN
Final rept. Jul-Sep 1969
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX
Pagination or Media Count:
Intraperitoneal i.p. infection of mice with Klebsiella pneumoniae was markedly suppressed by i.p. treatment with statolon or random copolymer of maleic acid and divinyl ether pyran given one day before infection. These two substances are known mostly for their capability to induce interferon and with it associated protection against viral infections. Their antibacterial effect, not reported previously, resembled that of bacterial endotoxin administered by the i.p. route one day before infection. The treatment with statolon, pyran or endotoxin did not impair immune response to the challenge organism, since the treated animals which survived one challenge were refractory to a later rechallenge.