Accession Number:

AD0711029

Title:

NEW ANTIMALARIAL AGENTS

Descriptive Note:

Final rept.

Corporate Author:

OHIO UNIV ATHENS

Personal Author(s):

Report Date:

1970-07-01

Pagination or Media Count:

15.0

Abstract:

A series of substituted naphthyridines was prepared and the compounds were screened for their antimalarial activity. Among these compounds, BNAC 30552, the 1,6-naphthyridine, substituted in position four by -NHCH3CHCH2 2NCH2CH32 was reported as active. In addition to these compounds a number of polyazaindenes were also prepared. Compound BNAC-29595, 1,8-dimethyl-imidazo 1,2-a-pyridinium iodide, showed complete sporozoite suppression. Most of the N-methyl salts of the polyazaindenes tested showed a high percentage of toxic deaths in the mosquito tests. It is suggested that these compounds, because of their potential biodegradability, might replace some of the currently available non-biologically degradable chemicals, such as DDT, in the control of mosquitos.

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE