HEMODYNAMIC AND RESPIRATORY EFFECTS OF DOPAMINE ON SEPTIC SHOCK IN THE MONKEY
OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
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This study explored the responses of the rhesus monkey in endotoxin or septic shock, to dopamine 3-hydroxytyramine and documents metabolic and respiratory effects of maintaining the cardiac output above control levels in those animals. A decrease in cardiac output and systemic arterial pressure occurred in all animals following infusion of endotoxin. Seven were then studied during increasing infusion rates of dopamine 0.5 to 10.0 mgmin and 5 animals received similar volumes of saline. Each increment in dopamine dose resulted in increased cardiac output. Heart rate, right atrial pressure, and systemic pressure were not altered significantly, but the systemic resistance decreased with each increment in dopamine administered. Two animals in shock after administration of live E. coli organisms had a similar response to dopamine. These parameters were unchanged in the animals that received saline, except at the highest infusion rates. In five animals the cardiac output was raised from 107 to 213 mlkgmin by a constant infusion of 1.0 to 1.5 mgmin of dopamine. Maintenance of the cardiac output above pre-shock levels did not reverse the metabolic acidosis, hyperventilation or increased alveoloarterial oxygen gradients which occurred during the shock period prior to the dopamine infusion.