IMMUNOLOGICAL REACTIONS IN VIRAL HEPATITIS.
Final technical rept. 1 Feb 68-30 Sep 69,
GENOA UNIV (ITALY) ISTITUTO DI MEDICINA DEL LAVORO
Pagination or Media Count:
Viral hepatitis sera VHS have been shown to possess mitosis-inhibiting MI and chromosome damaging CD activities on lymphocytes cultured in vitro in presence of phytohemagglutinin. These activities can be perpetuated by serial passage with filtered medium from cultures treated with VHS. The MI can be prevented by pooled human gamma globulins. When VHS from one patient was tested on lymphocytes from different donors large differences in inhibition were observed. Thus in plasma of donors there may be antibodies able to prevent the MI but not CD effect of VHS. Differences in results from different laboratories as to frequency of Australia antigen seem to be due partly to methods immunodiffusion vs. complement fixation and partly to different specificity of antisera. The frequency of AA in infectious and serum hepatitis, liver diseases, thalassemia, mongolism and lepromatous leprosy is reported. Screening of healthy blood donors from different regions showed the frequency of the AA carrier state to be much higher in Sardinia than in continental Italy. Author
- Medicine and Medical Research