The Chemistry and Pharmacology of Certain Compounds Affecting the Central Nervous System of Animals and Man
[Technical Report, Progress Report]
MICHIGAN UNIV ANN ARBOR
Pagination or Media Count:
EA 1476, EA 1477 and reserpine have numerous similar pharmacological effects in the dog when administered by the oral or intravenous route. EA 1476 and EA 1477 have qualitatively similar effects upon the cardiovascular system of the dog. EA 1476, EA 1477 and reserpine produce a state of tranquilization in the unanesthetized dog following intravenous administration. EA 1476 like reserpine can prolong the sleeping time of white mice induced by the intraperitoneal injection of hexobarbital. The electroencephalographic response of the unanesthetized curarized dog to 0.10 mgm.kgm. of EA 1476 administered intravenously is characterized by high voltage slow waves with some tendency to spindling. Hypothermia is an outstanding sign following intravenous administration of 1.0 mgm.kgm. of EA 1476. EA 1476 as well as reserpine depresses respiratory rate following intravenous administration to unanesthetized dogs.