Accession Number:

AD0707667

Title:

THE CHEMISTRY AND PHARMACOLOGY OF CERTAIN COMPOUNDS AFFECTING THE CENTRAL NERVOUS SYSTEM OF ANIMALS AND MAN. A PHARMACOLOGICAL COMPARISON OF EA 1476 (TETRAHYDROCANNABINOL) ISOMERS

Descriptive Note:

Progress rept.

Corporate Author:

MICHIGAN UNIV ANN ARBOR DEPT OF PHARMACOLOGY

Report Date:

1956-12-01

Pagination or Media Count:

10.0

Abstract:

EA 1476 OS and EA 1476 4018 produce a similar behavioral response in the unanesthetized dog with comparable intravenous doses. EA 1476 4018 produced death by cardiac arrest resulting from ventricular fibrillation in two out of five dogs who received intravenous doses of 1.0 mgm.kgm. EA 1476 OS appears to be more toxic now than when it was first evaluated in this laboratory two years ago. EA 1476 4018 may be slightly more toxic than EA 1476 OS with intravenous doses of 1.0 mgm.kgm.

Subject Categories:

  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE