Accession Number:

AD0707397

Title:

ANALYSIS OF THE DEVELOPMENT OF JAPANESE ENCEPHALITIS VIRUS ON THE BASIS OF PHOSPHATASE OR DEHYDROGENASE ACTIVITY IN INFECTED CENTRAL NERVOUS SYSTEM CELLS.

Descriptive Note:

Final rept. Feb 69-Feb 70,

Corporate Author:

NARA MEDICAL UNIV KASHIHARA CITY (JAPAN) DEPT OF ANATOMY

Personal Author(s):

Report Date:

1970-05-01

Pagination or Media Count:

20.0

Abstract:

The multiplication of Japanese encephalitis virus JEV inoculated intracerebrally in the mouse was examined in its hippocampus neurons and glial cells. The medium dense material appearing in the viral factory and ribosomes in the cytoplasm were associated with the development of JEV particles. Moreover, it was noticed that multiplication of viral particles was related with RNP particles within the mitochondrial matrix. ATPase activities were observed in maturing viral nucleoids and mitochondria. In the latter, final reaction products of ATPase were found surrounding a viral precursor. Nucleolar segregation appeared in neurons as well as in oligodendroglial cells, especially in the former occurred the decrease of size of nucleoli, showing often a doughnut-like shape. Author

Subject Categories:

  • Biochemistry
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE