Accession Number:

AD0707033

Title:

METABOLIC CHANGES IN MAN DURING SHORT EXPOSURE TO HIGH PRESSURE.

Descriptive Note:

Research paper,

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s):

Report Date:

1970-01-01

Pagination or Media Count:

5.0

Abstract:

The effects of compression and decompression on blood and urine chemistry in humans were assessed. Subjects were exposed to pressures up to 10 atmospheres absolute ATA, breathing air or a 2080 oxy-helium mixture for 12-1 hour periods, and 2 ATA of 100 oxygen for 12-hour. Samples of blood and urine were collected at depth and throughout the decompression period. Marked decreases in the excretion of sodium and calcium were found at depth on the air dives, these changes being completely reversible on decompression. Oxy-helium and pure oxygen did not alter the normal pattern of electrolyte excretion. A significant correlation between the degree of retention of sodium andor calcium and the total pressure of air was found. Significant increases in serum potassium and inorganic phosphorous and decreases in albumin also occurred in humans at 200 and 300 ft. of air. The alterations in electrolyte distribution in humans breathing air at pressure resemble the changes found with various anaesthetic agents and implicate the narcotic properties of the nitrogen component of air. Author

Subject Categories:

  • Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE