Accession Number:

AD0706557

Title:

MUTATIONS OF APATHOGENICITY AND SMALL PLAQUES IN THE TICK-BORNE ENCEPHALITIS VIRUS INDUCED BY N-NITROSOMETHYL UREA,

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

Report Date:

1970-05-11

Pagination or Media Count:

9.0

Abstract:

N-nitrosomethyl urea induces 100 mutations of apathogenicity in the virus of tick-borne encephalitis. The mutation from normal to small plaques are encountered 25 less frequently, and are not related to apathogenicity mutations. With respect to the degree of specificity, N-nitrosomethyl urea is superior to 1.4-bis-diasoacethyl butane, since the former evokes two types of mutation whereas 1.4-bis-diasoacethyl butane is characterized by three mutations. The nearly 100 mutation frequency brought about N-nitrosomethyl urea is achieved when the viability of the virus is decreased tenfold, and a 75 mutation frequency is obtained when the viability is decreased fivefold this has never been observed up to now in experiments with other physical and chemical mutagens. Author

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE