Accession Number:
AD0706557
Title:
MUTATIONS OF APATHOGENICITY AND SMALL PLAQUES IN THE TICK-BORNE ENCEPHALITIS VIRUS INDUCED BY N-NITROSOMETHYL UREA,
Descriptive Note:
Corporate Author:
FORT DETRICK FREDERICK MD
Personal Author(s):
Report Date:
1970-05-11
Pagination or Media Count:
9.0
Abstract:
N-nitrosomethyl urea induces 100 mutations of apathogenicity in the virus of tick-borne encephalitis. The mutation from normal to small plaques are encountered 25 less frequently, and are not related to apathogenicity mutations. With respect to the degree of specificity, N-nitrosomethyl urea is superior to 1.4-bis-diasoacethyl butane, since the former evokes two types of mutation whereas 1.4-bis-diasoacethyl butane is characterized by three mutations. The nearly 100 mutation frequency brought about N-nitrosomethyl urea is achieved when the viability of the virus is decreased tenfold, and a 75 mutation frequency is obtained when the viability is decreased fivefold this has never been observed up to now in experiments with other physical and chemical mutagens. Author
Descriptors:
Subject Categories:
- Microbiology