Accession Number:

AD0706353

Title:

MATERIALS FOR SUBSTANTIATION OF THE MAXIMUM PERMISSIBLE CONCENTRATION OF STREPTOMYCIN IN THE AIR OF INDUSTRIAL PREMISES,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Report Date:

1970-01-30

Pagination or Media Count:

13.0

Abstract:

Studies on the substantiation of the maximum permissible concentration MPC of streptomycin in the air of production premises were undertaken simultaneously at a number of hygiene and clinical establishments, which made it possible to assess the obtained results from the positions of specialists in different fields. This widely used antibiotic is obtained industrially by biosynthesis from Actinomyces globisporus streptomycini. In practice the hydrochloride and sulfate salts and also the complex salt of streptomycin with calcium chloride are applied. For the experiments we used white mice and rats 230 animals in conditions of acute and chronic experiment. Generalization and analysis of the materials presented in this article and comparison of data obtained through industrial and experimental observations made it possible to recommend that the MPC for streptomycin be set at 0.1 mgcu.m. This concentration was confirmed by the commission for establishing MPC of harmful substances in the air of industrial premises. Besides this, sanitation measures were developed which were transmitted to the Commission of the Chemical and Pharmaceutical industry. Author

Subject Categories:

  • Environmental Health and Safety

Distribution Statement:

APPROVED FOR PUBLIC RELEASE