ACTIVITY OF RAT LIVER ENZYMES RESPONSIBLE FOR GLYCOGEN METABOLISM AFTER WHOLE-BODY IRRADIATION
ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Pagination or Media Count:
The activities of liver enzymes involved in the breakdown and synthesis of glycogen have been investigated in rats exposed to 1200 rads midline kerma dose, free-in-air, of x rays or mixed gamma-neutron radiation. It was found that glycogen phosphorylase and amylo-1,6-glucosidase, both of which are involved in the breakdown of glycogen to 3glucose3 units, are greatly inhibited by both qualities of radiation. A considerable inhibition in the activity of amylo-1,4 to 1,6-trans-glucosidase branching enzyme was also observed. In contrast, it was found that the activity of UDP-glucose-glycogen transglucosylase which is responsible for the in vivo synthesis of 1,4- polysaccharides is greatly enhanced when the animal received x rays or mixed gamma-neutron radiation.