Accession Number:

AD0705979

Title:

INFLUENCE OF TEMPERATURE ON THE EFFECTS OF ENTEROTOXIN AND ENDOTOXIN IN MICE

Descriptive Note:

Progress rept. Jan-May 1969

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX

Personal Author(s):

Report Date:

1970-03-01

Pagination or Media Count:

11.0

Abstract:

For optimum health, the host must control the proliferation of endogenous bacteria and neutralize harmful toxins. Staphylococcal enterotoxin B SEB produced by gram-positive bacteria and lipopolysaccharide endotoxin LPS produced by certain gram-negative bacteria can exert synergistic effects when injected into homothermic animals mice. In both acclimatized and nonacclimatized animals, exposure to temperature extremes of 4 deg C or 35 deg C-- except in one instance--either hastens or increases death in the presence of SEB and LPS when compared to room temperature 24 deg C. This research determines experimentally that ambient temperature is a meaningful variable in the resistance or susceptibility of a mammal to certain common bacterial toxins.

Subject Categories:

  • Toxicology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE