EFFECTS OF HEAT STRESS ON CELLULAR STRUCTURE AND FUNCTION.
Technical rept., Jan 66-Dec 69,
PITTSBURGH UNIV PA
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The report demonstrates the effects of heat stress on kidney and liver tissues. It has been found that kidneys stressed to temperatures in excess of 41C undergo progressive damage. Observations utilizing the electron microscope show degenerative effects on cell organelles, especially mitochondria. Whole animals CF-1 mice heated in ambient temperatures of 40C to 45C for 30 minutes were used to determine the level at which 50 will survive. This ambient temperature was found to be 42C LD50. The liver of animals subjected to 43C rectal temperature for varying lengths of time demonstrate various levels of cellular degeneration. Mitochondrial swelling and degeneration, the formation of large lipid droplets and loss of glycogen are typical of heat stressed liver cells. The mitotic index was determined using tritium labelled thymidine. Mitosis is supPRESSED FOR A PERIOD OF TO HOURS AFTER HEAT-STRESS NEAR THE LD50 temperature, increases to more than twice the control value, and then returns to normal within 3 to 4 days. Author
- Stress Physiology