REVERSIBLE CHLORAMPHENICOL-INDUCED BONE MARROW DEPRESSION IN THE CHIMPANZEE.
AEROMEDICAL RESEARCH LAB (6571ST) HOLLOMAN AFB N MEX
Pagination or Media Count:
Chloramphenicol administered by intravenous or oral routes at a dose rate of 150 mgkgday to a total of 13 chimpanzees caused mild depression of erythrocyte precursors in bone marrow. The drug effect was characterized by a fall in reticulocyte count and a rise in serum iron level. Upon discontinuation of chloramphenicol, reticulocyte counts rose to a level higher than the pre-drug control values, and serum iron values returned to normal. The erythroid depression was not sufficient to cause a significant decrease in circulating red cell mass. Increased numbers of vacuolated proerythroblasts, frequently observed in cases of chloramphenicol toxicity in man, were observed in only one animal receiving the drug. Since this animal had hemorrhagic anemia as well, increase of the numbers of vacuolated precursor cells in the chimpanzee seemed associated with modifying factors rather than chloramphenicol administration alone. Author