COMPARISON OF SEPTIC SHOCK DUE TO GRAM-NEGATIVE AND GRAM-POSITIVE ORGANISMS.
OKLAHOMA UNIV MEDICAL CENTER OKLAHOMA CITY
Pagination or Media Count:
Cardiorespiratory effects of gram-negative and gram-positive septicemia were compared in the lightly anesthetized rhesus monkey. Thirty to 60 minutes after the onset of infusion of organisms, the cardiac output was higher and the peripheral resistance lower in the group that received staphylocci, as compared to the group that received E. coli. Subsequently, the cardiac output decreased, systemic pressure decreased, minute ventilation increased, alveolo-arterial oxygen tension gradients increased and arterial PCO2 and bicarbonate decreased as previously described in septic shock and to a comparable degree in both groups. These findings suggest a common host response to gram-positive and gram-negative organisms. Author
- Medicine and Medical Research