Accession Number:

AD0702668

Title:

A STUDY OF THE VARIABILITY OF THE CHIKUNGUNJA VIRUS. REPORT I. A NEW FACTOR AFFECTING THE MANIFESTATION OF THE PLAQUE-SIZE CRITERION,

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

Report Date:

1970-02-03

Pagination or Media Count:

7.0

Abstract:

A new factor was discovered, which affects the plaque-size criterion for the Chikungunja virus the age of the tissue culture. In a 120-hour old tissue culture the virus population has a homogeneous small-plaque characteristic, in distinction from the heterogeneous, basically large-plaque population in 48-hour old tissue cultures. This phenomenon is linked to a longer duration of the replication cycle on the basis of old cells and does not depend upon the action of inhibitors of the sulfonated polysaccharide type. In young tissue cultures, a sensitivity of the majority of the small-plaque variants to inhibitors has been detected. No differences have been established between large- and small-plaque variants of the virus with respect to adsorption properties and duration of the replication cycle. The small-plaque variant possesses a greater capacity for reproduction than does the large-plaque variant. Author

Subject Categories:

  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE