Accession Number:

AD0702423

Title:

EFFICACY SELECTED DRUGS AS PROPHYLACTIC AGENTS AGAINST DIROFILARIA IMMITIS INFECTION OF DOGS.

Descriptive Note:

Final rept. Feb-Nov 69,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Report Date:

1970-02-01

Pagination or Media Count:

13.0

Abstract:

Chemoprophylaxis of infection-reinfection with Dirofilaria immitis was obtained with diethylcarbamazine DEC citrate at a reduced concentration level with pound dogs divided into two sets of 5 dogs each experiment A. One set in experiment A received DEC citrate tablet, with the other set maintained as infected, nonmedicated controls. The dogs experiment A were euthanatized at 114 days after last injection of larvae. Adult heartworms were recovered from the infected, nonmedicated dogs. Worms were not found in the infected-reinfected, medicated set. The efficacy of Tiguvon, Tramisol, and DEC citrate liquid experiment B was also tested with 24 laboratory-standardized beagles divided into four sets of 6 dogs each. Each dog in experiment B infected sets received daily drug doses of either Tramisol, DEC citrate, or Tiguvon, with one remaining set maintained as infected, nonmedicated control. The dogs experiment B were euthanatized 138 to 155 days after injection of larvae. Adult heartworms were recovered from the infected, nonmedicated dogs. Worms were not found in the Tramisol or Tiguvon sets, but 2 worms were recovered in the DEC citrate set. Contraindication to the prophylactic use of DEC citrate was not observed clinically nor pathologically in experiments A and B. In experiment B there were contraindications to the use of Tramisol and Tiguvon both clinically and pathologically at the drug levels used in this experiment. Author

Subject Categories:

  • Animal Husbandry and Veterinary Medicine
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE