Accession Number:

AD0701226

Title:

THE EFFECT OF HYPEROXIA AND HYPOXIA ON FREE AND BOUND GAMMA-AMINOBUTYRIC ACID IN MAMMALIAN BRAIN,

Descriptive Note:

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT TORONTO DOWNSVIEW (ONTARIO)

Personal Author(s):

• Wood ,J. D.
• Watson ,W. J.

Report Date:

1969-05-14

Pagination or Media Count:

5.0

Abstract:

In rats and guinea pigs exposed to hyperoxic conditions, the levels of both bound and free gamma-aminobutyric acid in the brain were decreased, and under hypoxic conditions both were increased. A small but significant change in the proportion of gamma-aminobutyric acid in the bound form was observed in the exposed animals. The significance of the findings is discussed. Author

Descriptors:

• (*AMINO ACIDS
• BRAIN)
• (*BRAIN
• METABOLISM)
• (*HYPOXIA
• AMINO ACIDS)
• RODENTS
• EXPOSURE(PHYSIOLOGY)
• CHEMICAL ANALYSIS
• CONCENTRATION(CHEMISTRY)
• FATTY ACIDS
• OXYGEN
• PRESSURE BREATHING
• CONVULSIVE DISORDERS
• IN VIVO ANALYSIS
• CANADA

Subject Categories:

• Biochemistry
• Stress Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE