Accession Number:

AD0701224

Title:

THE CHOLINESTERASE-INHIBITORY CHARACTERISTICS OF PARPANIT AND ITS ANALOGUES IN RELATION TO THEIR PROTECTIVE EFFECTIVENESS IN THE TREATMENT OF SARIN-POISONED RODENTS,

Descriptive Note:

Corporate Author:

DEFENCE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s):

• Bannard,R. A. B.
• Helie,J. G.
• Price,Joan E.
• Coleman ,I. W.

Report Date:

1969-07-09

Pagination or Media Count:

5.0

Abstract:

Fifteen basic esters of 1-phenylcycloalkanecarboxylic acids were examined as reversible inhibitors of bovine erythrocyte acetylcholinesterase. All the compounds showed weak competitive or mixed inhibition of the enzyme. No correlation was found between the inhibitory potencies of the compounds and the protection which they afforded to sarin-poisoned rodents when administered together with 1-methylpyridinium-2-aldoxime methanesulfonate. Author

Descriptors:

• (*CYCLOPENTANES
• *PARASYMPATHOLYTIC AGENTS)
• (*GB AGENT
• PROTECTIVE TREATMENTS)
• CARBOXYLIC ACIDS
• CHOLINESTERASE INHIBITORS
• CANADA

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE