Accession Number:

AD0700727

Title:

CORNEAL ENDOTHELIUM IN VITRO: GROWTH INHIBITION AND STRUCTURAL CHANGES INDUCED BY HYDROCORTISONE.

Descriptive Note:

Final rept., 67-69,

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TEX

Personal Author(s):

• Lowry,George M.

Report Date:

1969-11-01

Pagination or Media Count:

15.0

Abstract:

Corneal endothelium from young albino rabbits was grown in tissue culture in the presence of supraphysiologic concentrations of hydrocortisone. Examination of the cultured cells by light- and electron microscopy disclosed abnormalities in mitochondria, endoplasmic reticulum, cytoplasmic granules, and nuclear chromatin. Although hydrocortisone impaired outgrowth, a given number of corneal endothelial cells grown in the presence of hydrocortisone covered more surface area on the growth substrate than did an equal number of control cells. Author

Descriptors:

• (*CORNEA
• CELLS(BIOLOGY))
• (*CELLS(BIOLOGY)
• *CORTICOSTEROID AGENTS)
• (*TISSUE CULTURE
• CORNEA)
• IN VITRO ANALYSIS
• MITOCHONDRIA
• CYTOPLASM
• GROWTH(PHYSIOLOGY)
• INHIBITION
• MORPHOLOGY(BIOLOGY)
• PATHOLOGY
• NUCLEI(BIOLOGY)

Subject Categories:

• Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE