SECONDARY EVALUATION OF ANTIMALARIAL AGENTS
Annual progress rept. 1 Jan-31 Dec 1969
IIT RESEARCH INST CHICAGO IL
Pagination or Media Count:
The objective of this research program is to screen potential antimalarial agents against Plasmodium berghei infections in mice. In addition to the use of blood induced normal and drug resistant infections, procedures were established for the use of sporozite induced infections of P. berghei yoelii in testing for casual prolactic as well as blood schizontocidal activity. Special studies were also made to differentiate the action of drugs that apparently exhibit both types of activity as well as to determine the period of infectivity of various tissues following sporozoite infection.