MULTIPLICATION AND ANTIBODY FORMATION OF JAPANESE ENCEPHALITIS VIRUS IN SNAKES
Technical Report,01 Aug 1968,31 Aug 1969
SEOUL NATIONAL UNIV (REPUBLIC OF KOREA) SEOUL Korea, South
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There is a hypothesis that Japanese encephalitis virus overwinters in the hibernating animals in the regions like Korea of which winter is so cold. The author has recently reported that injection of Japanese encephalitis virus in cold-blooded animals, snakes, induced proliferation of the virus and antibody formation, though irregular. In 1967, a strain of encephalitis virus was isolated from the snakes caught in the nature, and as a result of serologic test with 535 snakes, 40 of them proved to contain hemagglutination inhibition antibodies to the virus. And the proportion was higher in the snakes collected during the epidemic season than other times. In hemagglutination inhibition antibody test, the properties was higher when acetone extraction was done three or four times than twice. In 1968, as a result of serologic test with 412 collected snakes, neutralizing antibody to encephalitis virus was detected from 9 snakes, 2 of the total snakes.