Accession Number:

AD0699383

Title:

THE EFFECT OF LASER ENERGY ON CELLS IN TISSUE CULTURE.

Descriptive Note:

Annual summary rept. no. 2,

Corporate Author:

PASADENA FOUNDATION FOR MEDICAL RESEARCH CALIF DEPT OF LASER BIOLOGY

Personal Author(s):

Report Date:

1969-12-03

Pagination or Media Count:

21.0

Abstract:

Laser power at 2650 A produced cytolysis and inhibition in the migration of leukocytes. It also inhibited the activity of lactic dehydrogenase, and produced a photoproduct of uridylic acid with a reversible absorption change. Injured cells showed a loss of mitotic activity and an increased frequency of nuclear abnormalities. The focused argon microbeam produced visible lesions in nucleoli which showed a reduced uridine incorporation into RNA. Ablation of the nucleolar organizer sites on chromosomes showed a loss of genetic function in organizing a nucleolus. Concentrations of 0.0001 to 0.01 M ADP could mimic the promotion of blood clotting rates, platelet agglutination, and inhibition of cell growth, which were produced by chemicals that are released from ruby laser-traumatized cells. Author

Subject Categories:

  • Radiobiology
  • Microbiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE