COMPUTER SIMULATION OF A LIVING CELL: MULTILEVEL CONTROL SYSTEMS.
MICHIGAN UNIV ANN ARBOR LOGIC OF COMPUTERS GROUP
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A simple bacterial cell Escherichia coli has been modeled, and the input-output behavior of the model has been simulated as a program in FORTRAN IV for an IBM 36067 digital computer. Automata theoretic analysis of the homomorphic model underlying the computer simulation enables us to investigate the information content and complexity of the simulation and of the measurement space representing our data base. The simulated cell is able to adjust its enzymes and DNA to grow in different chemical environments using allosteric modification of enzymes, and repression of RNA synthesis. It grows at realistic rates and achieves limited metabolic stability. Author