Accession Number:

AD0698885

Title:

CHANGES IN THE REFLEX TIME, SPONTANEOUS MOTOR ACTIVITY, PHYSICAL ENDURANCE AND EFFICIENCY OF ANIMALS UNDER THE INFLUENCE OF RADIOPROTECTIVE AGENTS,

Descriptive Note:

Corporate Author:

FORT DETRICK FREDERICK MD

Personal Author(s):

Report Date:

1970-01-12

Pagination or Media Count:

9.0

Abstract:

Cystamine and N,N-tetramethylcystamine TMC in doses of 25 and 50 mgkg induce suppression of the reflex function of the spinal cord. N,N-difurfurylcystamine DFC induces a moderate lengthening of the time of the latent period of the flexion reflex in rabbits but only in a dose of 50 mgkg. Rapid intravenous injection of rabbits with large doses of cystamine and TMC causes toxic phenomena which are not observed when the preparations are injected slowly. Cystamine, TMC and DFC in doses of 10, 50, 100 and 150 mgkg depress the motor activity and physical endurance of white mice. Moreover, as dosages of the preparations are increased, the effect of their action increases. Cystamine and DFC in doses of 10, 50 and 100 mgkg reduce the static efficiency of white mice. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE