ANTIMALARIA DRUG SCREEN IN MONKEYS.
Annual rept. no. 2, 1 Jul 68-30 Jun 69,
PFIZER (CHAS) AND CO INC TERRE HAUTE IND BIOLOGICS DEVELOPMENT DEPT
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The objective of the study was the evaluation of antimalarial activity of compounds against blood-induced simian malaria. The program includes several areas of effort including 1 maintenance of a monkey colony of sufficient size to meet the testing demands, 2 determination of drug toxicity, and 3 determination of drug antimalarial effect. The tests were conducted in normal rhesus monkeys that weighed 2 - 3 kgm. A Malayan strain of Plasmodium knowlesi was used to infect the monkeys. The results of the study were organized into 2 groups - drugs tested individually and drugs tested in combinations. Work with each drug was further subdivided into toxicity test evaluations, antimalarial drug test evaluations and postsplenectomy observations. Author