Accession Number:
AD0698549
Title:
ANTIMALARIA DRUG SCREEN IN MONKEYS.
Descriptive Note:
Annual rept. no. 2, 1 Jul 68-30 Jun 69,
Corporate Author:
PFIZER (CHAS) AND CO INC TERRE HAUTE IND BIOLOGICS DEVELOPMENT DEPT
Personal Author(s):
Report Date:
1969-11-01
Pagination or Media Count:
36.0
Abstract:
The objective of the study was the evaluation of antimalarial activity of compounds against blood-induced simian malaria. The program includes several areas of effort including 1 maintenance of a monkey colony of sufficient size to meet the testing demands, 2 determination of drug toxicity, and 3 determination of drug antimalarial effect. The tests were conducted in normal rhesus monkeys that weighed 2 - 3 kgm. A Malayan strain of Plasmodium knowlesi was used to infect the monkeys. The results of the study were organized into 2 groups - drugs tested individually and drugs tested in combinations. Work with each drug was further subdivided into toxicity test evaluations, antimalarial drug test evaluations and postsplenectomy observations. Author
Descriptors:
Subject Categories:
- Pharmacology