Accession Number:

AD0698549

Title:

ANTIMALARIA DRUG SCREEN IN MONKEYS.

Descriptive Note:

Annual rept. no. 2, 1 Jul 68-30 Jun 69,

Corporate Author:

PFIZER (CHAS) AND CO INC TERRE HAUTE IND BIOLOGICS DEVELOPMENT DEPT

Personal Author(s):

Report Date:

1969-11-01

Pagination or Media Count:

36.0

Abstract:

The objective of the study was the evaluation of antimalarial activity of compounds against blood-induced simian malaria. The program includes several areas of effort including 1 maintenance of a monkey colony of sufficient size to meet the testing demands, 2 determination of drug toxicity, and 3 determination of drug antimalarial effect. The tests were conducted in normal rhesus monkeys that weighed 2 - 3 kgm. A Malayan strain of Plasmodium knowlesi was used to infect the monkeys. The results of the study were organized into 2 groups - drugs tested individually and drugs tested in combinations. Work with each drug was further subdivided into toxicity test evaluations, antimalarial drug test evaluations and postsplenectomy observations. Author

Subject Categories:

  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE