Accession Number:

AD0698467

Title:

TOXOGONIN: BLOOD LEVELS AND SIDE EFFECTS AFTER INTRAMUSCULAR ADMINISTRATION IN MAN.

Descriptive Note:

Technical rept.,

Corporate Author:

EDGEWOOD ARSENAL MD

Report Date:

1969-12-01

Pagination or Media Count:

25.0

Abstract:

Toxogonin, when given intramuscularly to 10 healthy young men, produced blood levels of oxime more than five times higher than those produced by equimolar doses of 2-PAMCl. Associated side effects included tachycardia, hypertension, and dose independent symptom complex consisting of a peroral warmth, paresthesia and hypalgesia, and a menthol taste. Some of the published data on the relative effectiveness of Toxogonin and 2-PAMCl, reviewed in the light of the current study, offer substantial reasons for further inquiry into Toxogonins therapeutic potential. Author

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE