SYNTHESIS AND CHARACTERIZATION OF 2-ETHYL-3-HEXANOL para-HYDROXYBENZOATE
FORT DETRICK FREDERICK MD
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2-Ethyl-3-hexanol p-hydroxybenzoate was synthesized and characterized by infrared and ultraviolet spectroscopy and thin-layer TLC and gas-liquid chromatography GLC. These methods proved the existence of stereoisomers and allowed the prediction of preferred conformations. The RR and SS enantiomers had a higher boiling point, a lower retention value on TLC, and were eluted faster on GLC than the RS and SR diastereoisomers. The ester exhibited antimicrobial activity against gram-positive bacteria and yeast, but not against gram-negative bacteria. The ester also exhibited sunscreen properties and was not toxic to animals.
- Organic Chemistry