THE PREPARATION OF PYRIDAZINES FOR ANTIMALARIAL TESTING.
PHILCO-FORD CORP NEWPORT BEACH CALIF AERONUTRONIC DIV
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The report describes three years of effort to examine the chemotherapeutic potential of the pyridazine nucleus in the treatment of the newer resistant strains of malaria. One hundred-sixteen new compounds were synthesized, characterized, and submitted to the Walter Reed Army Institute of Research for testing as antimalarial agents. Test results are available on all but two of these compounds. Although slight activity has been found in a few cases, none of the compounds tested has shown sufficient antimalarial activity to warrant further study. One of the compounds for which test results are not yet available is a close analog of the highly active quinoline methanols a cinnoline methanol. The majority of the compounds submitted were aminopyridazine derivatives, but several pyridazinones were included, as well as a few cinnoline and phthalazine derivatives and several non-amino derivatives of the pyridazine nucleus. Synthesized were analogs of the long-chain alkylaminopyridazines of chloroguanide of 1,4-bis-trichloromethylbenzene of the dialkylaminoalkylaminocinnolines and the closely related camoquine of trimethoprim and of the quinoline methanols. Author
- Organic Chemistry