PHARMACODYNAMICS OF A RADIOPROTECTIVE DRUG: 2-(1-DECYLAMINO) ETHANETHIOSULFURIC ACID
Final rept. Feb-May 1968
SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX
Pagination or Media Count:
One phase of the search for radioprotective agents is the study of the physiologic and pharmacologic mechanisms responsible for toxic and protective effects. In this study, the drug 2-1-decylaminoethanethiosulfuric acid WR-1607 was injected, according to different dosage schedules, into control and irradiated Macaca mulatta monkeys. Changes in hemograms and blood chemistries were measured, and clinical observations were recorded. The response in control animals appeared to be that to a temporary chemical challenge with prompt recovery within one week. In the irradiated animals, the response corresponded to a subacute radiation syndrome. In this experiment, WR- 1607 failed to mobilize physiologic mechanisms for protection against radiation injury. Further investigation of this drug as a radioprotectant should consider a different approach in method of administration.