Accession Number:

AD0692939

Title:

BIOCHEMICAL STUDIES ON THE TOXIC NATURE OF SNAKE VENOM

Descriptive Note:

Rept. no. 3 (Final), 6 Jun 1968-Jun 1969

Corporate Author:

KAOHSIUNG MEDICAL COLL (TAIWAN) DEPT OF BIOCHEMISTRY

Personal Author(s):

• Yang, Chen-Chung

Report Date:

1969-06-01

Pagination or Media Count:

33.0

Abstract:

Studies on the chemical properties of cobrotoxin have established its amino acid composition, and revealed that the toxin has a single peptide chain of 62 amino acids cross-linked by 4 disulfide bonds with amino terminal leucine and carboxyl terminal asparagine. In comparison with the entire sequence of toxin alpha from the venom of Naja nigricollis the similarities obviously must lie in its alike chemical structure. Knowledge of the sequence of cobrotoxin is required in order to understand the location of the essential amino acid residues required for the maintenance of the active conformation of this type. It is the purpose of this experiment to present the sequence of amino acids in cobrotoxin.

Descriptors:

• *VENOMS
• *REPTILES
• PEPTIDES
• MOLECULAR STRUCTURE
• TOXINS AND ANTITOXINS
• AMINO ACIDS
• TAIWAN
• THIN LAYER CHROMATOGRAPHY

Subject Categories:

• Biochemistry
• Toxicology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE