CONTINUED RESEARCH ON THE GENESIS OF ACTION POTENTIALS AND EXCITABLE TISSUES.
Final rept. l Jun-31 Dec 68
UPPSALA UNIV (SWEDEN) INST OF PHYSIOLOGY AND MEDICAL BIOPHYSICS
Pagination or Media Count:
The electrohydraulic excitability theory, previously applied to a biophysical analysis of the mechano-receptors, has now been used for a corresponding analyses of the normal and pathological heart rhythmicity. The basic concept has been the assumption of a coupling between the electric and mechanical events of the heart pacemakers i.e. a system of coupled oscillators with possibilities of delayed current andor pressure feed backs. The importance of a quiescent zone has been stressed. The existence of this zone may explain sudden failure of the rhythmical heart beating annihilation and also the possibility of initiation of rhythmicity of a quiescent heart. Under certain conditions of feed back reentry of electrical and mechanical factors can induce a severe rhythm disturbance similar to fibrillation observed in clinical medicine. The vulnerable zone of the heart cycle, discussed in the clinical literature, can be satisfactorily explained as closely related to the concept of a quiescent zone, defined in terms of the proposed, new excitability theory. Author
- Anatomy and Physiology