BIOLOGICAL PROPERTIES OF THE A22 VARIANT OF HOOF AND MOUTH DISEASE VIRUS
ARMY FOREIGN SCIENCE AND TECHNOLOGY CENTER CHARLOTTESVILLE VA
Pagination or Media Count:
Hoof and mouth disease virus A22, adapted over the course of 149 passages to the organism of the rabbit, as a result of further passaging in CK culture at 24 degrees lost the ability to propagate at an increased temperature and acquired the ability to propagate at low temperatures and to form small negative colonies, reduced the pathogenic properties for mice, rabbits, and guinea pigs. The hoof and mouth disease virus strain obtained proved to be innocuous and immunogenic for cattle upon testing in preliminary experiments. The methods used for evaluating the modified strain according to a series of markers proved to be suitable for determining the degree of attenuation of hoof and mouth disease virus A22.
- Animal Husbandry and Veterinary Medicine