BIOCHEMICAL PHARMACOLOGY OF HYDRAZINES TOXICITY
Final rept. Mar 1966-Feb 1968
SAN FRANCISCO UNIV CA INST OF CHEMICAL BIOLOGY
Pagination or Media Count:
The toxic action of 1-1-dimethylhydrazine UDMH and monomethylhydrazine MMH may be mediated by the inactivation of pyridoxal in the brain. One possibility considered was the formation of a hydrazone between the pyridoxals and the substituted hydrazine. Pyridoxal dependent enzymes were investigated. UDMH and MMH inhibited both glutamic acid decarboxylase and DOPA decarboxylase. Transaminases amino transferases which required alpha-ketoglutaric acid as a substrate were not affected by the hydrazines tested. Further work was conducted to refine an ultrasensitive bioassay method for the detection of each congener of the vitamin B6 group. The microorganisms investigated for the assay were a neurospora and a yeast. Some indirect evidence was obtained which implies that UDMH injected intraperitoneally can be detected in the central nervous system. A mathematical model for hydrazines-induced convulsions was developed. It is now possible to predict the time lapse after administration of the convulsigen and the onset of seizure if only three data points are given.
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