CLINICAL-MORPHOLOGICAL AND IMMUNOLOGICAL PARALLELS IN GUINEA PIGS INFECTED WITH VACCINE AND VIRULENT STRAINS OF R. BURNETTI
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
In guinea pigs a vaccine strain of R. burnetti does not cause a clinically expressed illness, but leads to the formation of specific complement- fixing antibodies, the titers of which are considerably lower than during infection with the same dose of a highly virulent strain. No difference was revealed in the degree of expression of morphological changes in the organs of guinea pigs which were infected with virulent and vaccine strains of R. burnetti. The morphological changes described can be characterized as connected with the formation of immunity to the particular causative agent.
- Medicine and Medical Research