PATHOGENESIS AND MORPHOLOGICAL CHANGES IN THE LUNGS OF MICE DURING EXPERIMENTAL INFECTION WITH THE PARAINFLUENZA SENDAI VIRUS
ARMY BIOLOGICAL LABS FREDERICK MD
Pagination or Media Count:
After the intranasal infection of mice with the parainfluenza virus Sendai in doses of 1000 LD50 the virus not only multiplied easily in the lungs, but was also detected in the blood, heart, liver, and brain in the heart of mice an incomplete virus in formed hemagglutinins are revealed in the lungs only in the later periods of development of infection. Histopathological changes in the lungs of mice which were infected with the parainfluenza Sendai virus are characterized by comparatively weakly expressed necrotic destructive processes in the epithelium of the bronchi in comparison with infection by the adapted virus of influenza. At first there sets in a leukocytic infiltration of the wall of the bronchus and proliferation of the bronchi which acquires a polynuclear disposition. In the last days of life of the mice pneumonia with a leukocytic exudate in the alveoli develops. Inclusion bodies, detected during parainfluenza infection with the Sendai virus in the cells of epithelium, trachea, bronchi, and alveoli, do not differ from the cytoplasmic inclusions which are described by a number of authors for influenza.
- Medicine and Medical Research