CLINICAL EVALUATION OF TRANSFUSED BLOOD AFTER LONG-TERM STORAGE IN ACD WITH ADENINE.
ARMY MEDICAL RESEARCH LAB FORT KNOX KY
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Liquid whole blood collected in ACD with and without adenine was transfused into patients having various forms of blood loss. The units collected in ACD alone had been stored 14-28 days, while those units in adenine had been stored 28-42 days. Of the 771 units in the study, 545 were transfused into 295 patients. A total of 276 units was in adenine and was given to 130 patients. Little or no reaction could be detected from clinical observation and selected laboratory tests related to the transfusion andor solution. Isotope labeling of some of the transfused units given to over 80 patients provided an estimate of the 24-hour posttransfusion survival and the results were similar to the average survival obtained in normal subjects after single-unit transfusions. The apparent lack of toxicity, yet adequate support of the bleeding patient, based on clinical and laboratory findings, suggested that blood stored in adenine was useful after longer storage periods than blood stored in ACD alone. The survival tests, compared against the 70 guideline, suggested that satisfactory survival was present even after 35 days of storage or possibly even after 42 days. Author
- Medicine and Medical Research