A FURTHER SURVEY OF COMPOUNDS FOR RADIATION PROTECTION
Final rept. Jan 1961-Apr 1965
CHICAGO UNIV IL USAF RADIATION LAB
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The report summarizes the results obtained with 617 compounds tested for their radioprotective activity in adult male mice irradiated with a control- demonstrated LD99 of 800 R 250 kvp x-rays. A compound was considered to exhibit radioprotective activity if it 1 permitted any of the treated mice to survive for 30 days after the otherwise lethal whole-body x-irradiation or 2 increased the median survival time of treated animals by 5 days or more beyond the median survival time of the untreated control mice 9 plus or minus 3 days. Of the 617 compounds tested, 245 successfully passed one or both of the stated specifications. Additionally, data are offered to allow comparisons of chemically related groups for structure-activity relationships, and to indicate the types of structures which offer the greatest promise as a source of more effective and less toxic radioprotective agents.