Accession Number:

AD0691175

Title:

INFLUENCE OF BETA SYMPATHETIC BLOCKADE (PROPRANOLOL) ON THE HEMODYNAMICS OF HYPERTHYROIDISM,

Descriptive Note:

Corporate Author:

NAVAL HOSPITAL PHILADELPHIA PA DEPT OF MEDICINE

Report Date:

1968-03-29

Pagination or Media Count:

8.0

Abstract:

The circulatory effects of propranolol 0.15 to 0.38 mg. per kg. given intravenously were studied in seven hyperthyroid patients during periods of rest and exercise before and after the administration of propranolol and the results conpared with propranolol effects in euthyroid subjects. Indices of left ventricular work LVWI stroke work SWI left ventricular tension time TTI mean systolic ejection rate MSER and cardiac output CI were derived in the usual manner. The mean rate of left ventricular isovolumetric pressure development MRIPD was employed as an index of contractility. It was concluded that beta adrenergic blockade attenuates the positive inotropic and chronotropic effects of thyroid hormone and presumably reduces the exaggerated myocardial oxygen requirement of thyrotoxicosis. Myocardial efficiency is thereby improved. The study supports the concept that the cardiac effects of thyroid hormone are mediated at least in part via the sympathetic nervous system. Author

Subject Categories:

  • Anatomy and Physiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE