STUDIES ON THE CHEMOTHERAPY OF RODENT MALARIA AND DRUG RESISTANCE.
Final technical rept. Oct 67-Mar 69,
LIVERPOOL SCHOOL OF TROPICAL MEDICINE (ENGLAND) DEPT OF PARASITOLOGY
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The development of techniques for the evaluation of the level and mode of action of antimalarial drugs against normal and drug-resistant strains has been initiated. Much reliance is being placed upon variations of the bioassay techniques. Many baseline data have been accumulated by these and the conventional suppressive tests for future reference. Basic studies on the production and characteristics of different drug-resistant strains of the rodent parasite Plasmodium berghei have been supplemented by cytochemical and ultrastructural observations that have revealed important functions such as that of mitochondrial respiration, hitherto not known to occur in intraerythrocytic stages of rodent malaria parasites. The techniques developed are now being employed to study the action of old and new antimalarial drugs on the various stages of normal and drug-resistant strains. Other fundamental observations indicate possible leads to the prevention of drug resistance by the use of drug combinations, to the evolution of different strains in nature through temperature factors and to the rapid dissemination of chloroquine-resistant strains through a biological advantage imposed by chloroquine on such organisms. Author