THE EFFECT OF VARIOUS STRESSES ON THYROID FUNCTION.
Final rept. 15 Mar 67-14 Mar 69,
HARBOR GENERAL HOSPITAL TORRANCE CALIF ATTENDING STAFF ASSOCIATION
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A study was made of the effect of epinephrine, thyrotropin TSH and the long-acting thyroid stimulator LATS on various aspects of thyroid function. Epinephrine administered to the normal human caused relatively little effect on thyroid function per se, but produced a marked shift of tissue-bound thyroxine into the plasma thyroxine compartment. This may be a significant accompaniment of catecholamine action. LATS and TSH were compared in various ways. The actions of the two substances were very similar in vivo, except that LATS was slower in onset. When studied in vitro, the two substances were identical in effects and there was no longer even a difference in time of onset of action. LATS and TSH each exhibited a latent period of approximately 10 minutes before induction of a significant increase in glucose oxidation and endocytosis in canine thyroid slices. Another similarity between the two stimulators was that all evidence of thyroid stimulation in vitro was prevented by the presence of one of several lysosome stabilizers, such as chlorpromazine, and by the B-adrenergic blocker, propranolol. These agents also inhibited the in vitro effects of dibutyryl cyclic-AMP on thyroid slices. Author
- Stress Physiology