MUSTARD: THE RELEVANCE OF DNA DAMAGE TO THE DEVELOPMENT OF THE SKIN LESION.
Technical rept. Aug 67-Jan 69,
EDGEWOOD ARSENAL MD
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The object of this study was to determine the importance and relevance of DNA damage in sulfur-mustardH-induced skin lesions. It was found that caffeine, proflavine, and acriflavine, three DNA repair inhibitors, significantly potentiated the vesicant action of sulfur mustard. Biochemical evidence obtained from biopsied sections of rabbit skin indicated that H caused approximately a 95 percent inhibition of normal semiconservative DNA replication and initiated DNA repair replication. The DNA repair inhibitors were also found to be effective in this system. It was concluded that a The vesicant action of H is due to an initial damage to DNA b rabbit skin possesses an active but inhibitable DNA repair capability and c the failure to repair DNA results in a more severe skin lesion following an almost uneventful latent period and d cellular breakdown products stimulate reproduction of basal and hair follicle cells. Author
- Medicine and Medical Research
- Chemical, Biological and Radiological Warfare