NONSPECIFIC STABILITY OF CELLS TO BACTERIAL TOXINS. THE CONCEPT OF CELL STRESS
ARMY BIOLOGICAL LABS FREDERICK MD
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It was established that in the presence of interferon there is an increase of stability of cells from a culture of chick embryo to the cytopathogenic effect of diphtheria and staphylococcus toxins, and also the endotoxin of B. typhi. This increase of stability was also preserved after removal of interferon. Interference of virus was also obtained with the cytopathogenic action of diphtheria toxin and the endotoxin of B. typhu. It has been established that interferon does not exert a direct inhibiting effect on toxin in vitro. Its activity, just as during the action of viruses, is expressed indirectly through the cell. The development of interferon is the manifestation of the adaptation reaction of the cell, as a result of which an increase of stability to various stimuli emerges. The reaction of interference of viruses is only its partial manifestation. Processes, leading to the emergence of the stated condition, are characterized quite sufficiently from the position of the protein theory of stimulation, according to which the nature of the response reaction of a cell is determined primarily by the protein transformations originating in it.