A NEW MECHANISM FOR THE CALCIFICATION OF SKELETAL TISSUES.
WALTER REED ARMY MEDICAL CENTER WASHINGTON D C ARMY MEDICAL BIOMECHANICAL RESEARCH LAB
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A new mechanism for the calcification of skeletal tissue is proposed in which ATP present in high levels in the mineralizing zone of cartilage first complexes calcium. The calcium complex is subsequently hydrolyzed to calcium acid pyrophosphate and then to hydroxy apatite. During the process, adenosine and orthophosphoric acid are also formed which combine to regenerate ATP. The process is thus cyclical. The mechanism describably by balanced chemical equations is in accord with experimental observations found in the literature and data reported herein. Author