A RATIONALE FOR THE PREPARATION OF NONTHROMBOGENIC MATERIALS.
WALTER REED ARMY MEDICAL CENTER WASHINGTON D C ARMY MEDICAL BIOMECHANICAL RESEARCH LAB
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It is postulated that negative charges, per se, are insufficient to impart thromboresistance to a polymer surface. Rather, it is hypothesized that a specific steric array of negative charges is required certain distribution favoring thromboresistance and others either not imparting thromboresistance or, indeed, enhancing the possibility of thrombus formation. The distances between charges required may be a function of whether an intramolecular calcium bridge may be formed. It is proposed that truly neutral surfaces may be more suitable as thromboresistant surfaces. Author
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