Accession Number:

AD0687654

Title:

GAMMA-RADIOLYSIS OF DISULFIDES IN AQUEOUS SOLUTION. II. D-PENICILLAMINE DISULFIDE,

Descriptive Note:

Corporate Author:

DEFENSE RESEARCH ESTABLISHMENT OTTAWA (ONTARIO)

Personal Author(s):

Report Date:

1968-07-10

Pagination or Media Count:

9.0

Abstract:

The gamma-radiolysis of D-penicillamine disulfide PenSSPen in an aqueous solution has been studied under aerated and deaerated conditions. G values were determined for the following products penicillamine sulfinic acid PenSO2H, penicillaminic acid PenSO3H, beta-hydroxyvaline PenOH, 2-amino-3-methylbut-3-enoic acid HOOC.CHNH2.CCH3CH2, penicillamine PenSH, penicillamine disulfide-S-monoxide PenSOSPen, valine PenH, penicillamine trisulfide PenSSSPen, and ammonia. The low yield of PenSO3H in aerated solution indicated that PenSOH did not react with oxygen or O2-. Experiments with OH radicals produced chemically TiCl3H2O2 and irradiations with cysteine or penicillamine present were used to confirm these reactions. These and the other reactions were tested with radical scavengers formate and monochloroacetate ions and nitrous oxide. Author

Subject Categories:

  • Biochemistry
  • Radiation and Nuclear Chemistry

Distribution Statement:

APPROVED FOR PUBLIC RELEASE